The 3-star Santa Isabel Hotel Portimao is located 2.7 km from Careanosy Beach, in the centre of Portimao, and offers rooms with city views. The guest house offers Wi-Fi in public areas as well as a 24-hour front desk, late check-out, and express check-out.

Situated within reach of Vau Beach, this smoke-free hotel also gives access to such sports venues as the Portimão Stadium, which is around 700 metres away. Alvor Boardwalk is within 6 km of the Santa Isabel, while Largo do Dique bus stop is approximately 10 minutes' walk away. Guests can easily get in touch with the history of Portimao by visiting the cultural Igreja de Nossa Senhora da Conceicao Heritage Monument, located not far from the property. For those travelling from afar, Portimao airport is 10 minutes' drive away.

Churrasqueira de Portimao offers a selection of Portuguese delicacies and lies only a 5-minute walk from Santa Isabel Hotel.